During the Klondike Gold Rush, a misanthropic cattle driver and his talkative elderly partner run afoul of the law in Alaska and are forced to work for a saloon owner to take her supplies into a newly booming but lawless Canadian town.
Infamous outlaw Harland Rust breaks his estranged grandson Lucas out of prison, after Lucas is convicted to hang for an accidental murder. The two must outrun legendary U.S Marshal Wood Helm and bounty hunter Fenton "Preacher" Lang who are hot on their tails. Deeply buried secrets rise from the ashes and an unexpected familial bond begins to form as the mismatched duo tries to survive the merciless American Frontier.
John Henry returns to his hometown in hopes of repairing his relationship with his estranged father, but a local gang is terrorizing the town. John Henry is the only one who can stop them, however he has abandoned both his gun and reputation as a fearless quick-draw killer.
A bandit kidnaps a Marshal who has seen a map showing a gold vein on Indian lands, but other groups are looking for it too, while the Apache try to keep the secret location undisturbed.
Following the Civil War, headstrong rancher Thomas Dunson decides to lead a perilous cattle drive from Texas to Missouri. During the exhausting journey, his persistence becomes tyrannical in the eyes of Matthew Garth, his adopted son and protégé.
The Apache Indians have reluctantly agreed to settle on a US Government approved reservation. Not all the Apaches are able to adapt to the life of corn farmers. One in particular, Geronimo, is restless. Pushed over the edge by broken promises and necessary actions by the government, Geronimo and thirty or so other warriors form an attack team which humiliates the government by evading capture, while reclaiming what is rightfully theirs.
Lawman Wyatt Earp and outlaw Doc Holliday form an unlikely alliance which culminates in their participation in the legendary Gunfight at the O.K. Corral.
Running from the law after a bank robbery in Mexico, Dad Longworth finds an opportunity to take the stolen gold and leave his partner Rio to be captured. Years later, Rio escapes from the prison where he has been since, and hunts down Dad for revenge. Dad is now a respectable sheriff in California, and has been living in fear of Rio's return.
Cowboy Riobaldo is attracted to same sex Diadorim, not knowing that "he" is a girl dressed in man's clothes. After Diadorim's father is killed, she swears revenge, being joined by Riobaldo in this mission.
John Russell, disdained by his "respectable" fellow stagecoach passengers because he was raised by Indians, becomes their only hope for survival when they are set upon by outlaws.
Nineteen year old pioneer woman Marty has recently married. She goes west with her husband Clem, hoping to start a new life. But Clem unexpectedly dies, and Marty finds herself alone, two months pregnant. Widower Clark offers her a marriage of convenience: she needs food and money, and he needs someone to take care of his daughter Missie. She accepts his proposal as a temporary solution.
While filing for a divorce, beautiful ex-stripper Roslyn Taber ends up meeting aging cowboy-turned-gambler Gay Langland and former World War II aviator Guido Racanelli. The two men instantly become infatuated with Roslyn and, on a whim, the three decide to move into Guido's half-finished desert home together. When grizzled ex-rodeo rider Perce Howland arrives, the unlikely foursome strike up a business capturing wild horses.
In the mid-19th century, Senator William J. Tadlock leads a group of settlers overland in a quest to start a new settlement in the Western US. Tadlock is a highly principled and demanding taskmaster who is as hard on himself as he is on those who have joined his wagon train. He clashes with one of the new settlers, Lije Evans, who doesn't quite appreciate Tadlock's ways. Along the way, the families must face death and heartbreak and a sampling of frontier justice when one of them accidentally kills a young Indian boy.
Owen Thursday sees his new posting to the desolate Fort Apache as a chance to claim the military honour which he believes is rightfully his. Arrogant, obsessed with military form and ultimately self-destructive, he attempts to destroy the Apache chief Cochise after luring him across the border from Mexico, against the advice of his subordinates.